Stored memories enter a temporary state of vulnerability following retrieval known as 'reconsolidation', a process that can allow memories to be modified to incorporate new information.Nicole C. Ferrara 1,2 Janine L. Kwapis 3 Sydney Trask 4,5* 1 Discipline of Physiology and Biophysics, Rosalind Franklin University, North Chicago, IL, United States 2 Center for Neurobiology of Stress Resilience and Psychiatric Disorders, Rosalind Franklin University, North Chicago, IL, United StatesTimothy J Jarome, Craig T. Werner, Janine L. Kwapis, F. Helmstetter. Biology, Psychology. PloS one. 2011; TLDR. Evidence is provided that UPS-mediated protein degradation is a major regulator of synaptic plasticity necessary for the formation and stability of long-term memories at amygdala synapses during memory formation and retrieval.Europe PMC is an archive of life sciences journal literature.This research was supported by the National Institutes of Mental Health (NIMH) Grant R01MH069558 to Fred J. Helmstetter and NIMH Grant F31MH090685 to Janine L. Kwapis. Recommended articles References (103)International Journal of Molecular Sciences Editorial Special Issue “Molecular Mechanisms of Memory Formation and Modification” Timothy J. Jarome 1,2,* and Janine L. Kwapis 3,4,* Citation: Jarome, T.J.; Kwapis, J.L. Special Issue “Molecular MechanismsM. Nonet. Biology. bioRxiv. 2023. TLDR. The rRMCE toolbox provides a platform for developing further innovative uses of RMCE to create complex genetically engineered tools, and genetic and molecular reagents designed to facilitate customization of both targeting vectors and landing sites are described. 1.Added Creator Janine L. Kwapis November 15, 2021 13:11 by Researcher Metadata Database. Published November 15, 2021 13:11 by Researcher Metadata Database. Updated February 28, 2022 22:44 ...Aug 20, 2018 · The work of Y.L., C.M., S.C., and P.B. was in part supported by NSF grant IIS- 1550705, DARPA grant D17AP00002, and NIH GM123558 to P.B. E.M. was supported by a long-term EMBO post-doctoral fellowship and an ARC Foundation award and work in the P.S.-C. lab was supported by grants from the National Institutes of Health, INSERM, and the Novo ... Janine L. Kwapis 1, Jada J. Hallengren 2, Scott M. Wilson 2 and Fred J. Helmstetter 1, 3; 1 Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA 2 Department of Neurobiology ...select article Epigenetic mechanisms in fear conditioning: implications for treating post-traumatic stress disorderEpigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. by Janine L Kwapis, Yasaman Alaghband, Enikö A Kramár, Alberto J López, Annie Vogel Ciernia, André O White, Guanhua Shu, Diane Rhee, Christina M Michael, Emilie Montellier, Yu Liu, Christophe N Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P Matheos, Marcelo A Wood.C.L. Bennett. Pages 44-57 View PDF. Article preview. select article Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI) ... Alexandria R. McKenna, ... Janine L. Kwapis. Pages ...Contributors: Janine L. Kwapis; Timothy J. Jarome; Marieke R. Gilmartin; Fred J. Helmstetter Show more detail. Source: Marieke Gilmartin via Crossref Metadata Search Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial …Welcome to the Kwapis Lab! We are located at the University Park campus of Pennsylvania State University in the department of Biology . Our lab is part of the Eberly College of Science , and we’re affiliated with the Huck Institutes of the Life Sciences .Alaghband Y, Kwapis JL, López AJ, White AO, Aimiuwu OV, Al-Kachak A, Bodinayake KK, Oparaugo NC, Dang R, Astarabadi M, Matheos DP, Wood MA (2017) Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory.The Neuroscience section of the Current Protocols journal covers research methods involving molecular pathways, synaptic transmission, behavioral techniques & imaging.Jun 6, 2019 · This work was supported by National Institutes of Health Grants MH101491, AG051807, and AG050787 to M.A.W., the National Institute on Aging Grants F32 AG052303 and K99 AG056596 to J.L.K., and in part by the Intramural Research Program of the National Institute on Aging. We thank Dr. Timothy Bredy for his help developing the HA-Nr4a1 virus. Oct 11, 2019 · Fear of movement-related pain leads to two types of avoidance behavior: excessive avoidance and pain-inhibited movement. Excessive avoidance is an absence of movement by fear, and pain-inhibited movements involve a change in motor behavior for the purpose of protecting the painful part. Here, we sought to clarify the acquisition process and adaptation of fear for each avoidance behavior ... Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during complex neural processes like memory consolidation. Individually, the molecular components and action of each of these sys …Brief Communication The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation Timothy J. Jarome,1 Janine L. Kwapis,1 Jada J. Hallengren,2 Scott M. Wilson,2 and Fred J. Helmstetter1,3 1Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA; 2Department of Neurobiology, University of Alabama, Birmingham, Alabama 35294, USAJanine L. Kwapis, Craig T. Werner, Ryan G. Parsons, Georgette M. Gafford and Fred J. Helmstetter 1; Psychology Department, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA; Abstract. Numerous studies have indicated that maintaining a fear memory after retrieval requires de novo protein synthesis. ...Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter, 2015, Communications in behavioral biology. Part A: [Original articles] on p. 110-116Hervera A, Zhou L, Palmisano I, et al. (2019) PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure. The Embo Journal Kwapis JL, Alaghband Y, López AJ, et al. ( 2019 ) HDAC3-mediated repression of the family contributes to age-related impairments in long-term memory.We investigated how sex modulates metabolic connectivity alterations in probable dementia with Lewy bodies (pDLB). We included 131 pDLB patients (males/females: 58/73) and similarly aged healthy controls (HC) (male/female: 59/75) with available (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans.Janine L. Kwapis [email protected] Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, Pennsylvania. Corresponding author: [email protected] Search for more papers by this author. Destiny S. Wright, Destiny S. Wright.Janine Kwapis, assistant professor of biology at Penn State, appointed as the Paul Berg Early Career Professor in the Biological Sciences About Eberly Leadership Meet the Dean Dean's Executive Team Sustainability Council Vision, Mission, and …Yasaman Alaghband, Enikö Kramár, Janine L. Kwapis, Earnest S. Kim, Thekla J. Hemstedt, Alberto J. López, André O. White, Amni Al-Kachak, Osasumwen V. Aimiuwu, Kasuni K. Bodinayake, Nicole C. Oparaugo, Joseph Han, K. Matthew Lattal and Marcelo A. Wood. ... (DA025922) to K.M.L. and M.A.W., the National Institute of Mental …Author links open overlay panel Yasaman Alaghband a b c, Janine L. Kwapis a b d, Alberto J. López a b c, André O. White a b c 1, Osasumwen V. Aimiuwu a b c 2, Amni Al-Kachak a b c 3, Kasuni K. Bodinayake a b c, Nicole C. Oparaugo a b c, Richard Dang aJanine L. Kwapis, Marcelo A. Wood. Biology; Research output: Contribution to journal › Review article › peer-review. 69 Citations (SciVal) Overview; Fingerprint; Abstract. Post-traumatic stress disorder (PTSD) and other anxiety disorders stemming from dysregulated fear memory are problematic and costly. Understanding the molecular ...Christopher W. Butler, 1 Ashley A. Keiser, 1 Janine L. Kwapis, 2 Nicole C. Berchtold, 1 Vanessa L. Wall, 1 Marcelo A. Wood, 1 and Carl W. Cotman 1 Christopher W. Butler 1 Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92617, USAJanine L. Kwapis, Timothy J. Jarome, Fred J. Helmstetter. Biology; Research output: Contribution to journal › Article › peer-review. 14 Scopus citations. Overview; Fingerprint; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. Whether this ...The retrosplenial cortex (RSC) is known to play a role in the retrieval of context memory, but its involvement in memory formation and consolidation is unclear. To better characterize the role of the RSC, we tested its involvement in the formation and ...AU - Kwapis, Janine L. AU - Trask, Sydney. AU - Pullins, Shane E. AU - Helmstetter, Fred J. N1 - Funding Information: This work was supported by National Institute of Health (NIH) grants MH112141 and AG053854 (FJH) and startup funds from the College of Agricultural and Life Sciences and the College of Science at Virginia Tech (TJJ). Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp, Marcelo A. WoodAbstract. Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association.The NR2B subunit confers unique properties to the NMDAR and may differentially regulate these two fear memories.The Editors depend heavily on outside reviewers in forming opinions about papers submitted to JNeurosci and would like to formally thank the following individuals for their help during the past year.. Esther Aarts. Ishmail Abdus-Saboor. Ted Abel. Moshe AbelesIt is established that CAMKII is active within the perirhinal region between ∼20 and 100 min following learning and then returns to baseline, which is essential for the consolidation of long‐term object recognition memory. The aim was to investigate the role of calcium‐calmodulin‐dependent protein kinase (CAMK)II in object recognition memory.Janine Kwapis Bio & Links Publications In the News Research Summary Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments. Huck Graduate Students Lauren Bellfy Chad Brunswick Hannah Boyd Huck Affiliations Molecular, Cellular, and Integrative Biosciences NeuroscienceJanine L. Kwapis a and Fred J. Helmstetter a Janine L. Kwapis a Department of Psychology, University of Wisconsin-Milwaukee, 2441 E. Hartford Ave., Milwaukee, WI 53211, USAWe have previously shown that trace fear extinction requires the RSC (Kwapis et al., 2014) and have hypothesized that trace memory may be stored in a distributed cortical network that includes prelimbic and retrosplenial cortices (Kwapis et al., 2015). Whether the RSC participates in acquiring and storing cued trace fear, however, is currently ...Destiny S. Wright, 1 Kasuni K. Bodinayake, 1 and Janine L. Kwapis 1, * Destiny S. Wright 1 Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, PA, USARead the latest Research articles from Neuropsychopharmacology. Effects of a Serotonin 2C Agonist and a 2A Antagonist on Actigraphy-Based Sleep Parameters Disrupted by Methamphetamine Self ...Author(s): Kwapis, Janine L; Alaghband, Yasaman; Kramár, Enikö A; López, Alberto J; Vogel Ciernia, Annie; White, André O; Shu, Guanhua; Rhee, Diane; ...The Neuroscience section of the Current Protocols journal covers research methods involving molecular pathways, synaptic transmission, behavioral techniques & imaging.Europe PMC is an archive of life sciences journal literature. https://orcid.orgJanine L. Kwapis. Janine L. Kwapis. Scilit Preprints.org Google Scholar * Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, PA 16802, USA * Author to whom correspondence should be addressed.Janine L. Kwapis1, Sydney Trask 1, Shane E. Pullins1 & Fred J. Helmstetter1 Associations learned during Pavlovian fear conditioning are rapidly acquired and long lasting, providing an ideal model for studying long-term memory formation, storage, and retrieval. During retrieval, theseThis work was supported by the National Institute on Drug Abuse (DA025922 to M.A.W. and DA041838 to A.J.L.), the National Institute of Mental Health (MH101491 to M.A.W. and G.L., and support to A.J.L.), the National Institute of Neurological Disorders and Stroke (NS085709 to G.L. and NS105217 to A.J.L.) and National Institute of General Medical ...Numerous studies have suggested a role for ubiquitin-proteasome-mediated protein degradation in learning-dependent synaptic plasticity; however, very little is known about how protein degradation is regulated at the level of the proteasome during memory formation.Janine L. Kwapis, Fred J. Helmstetter∗ Department of Psychology, University of Wisconsin-Milwaukee, 2441 E. Hartford Ave., Milwaukee, WI 53211, USA a r t i c l e i n f o Article history: Received 12 August 2013 Received in revised form 16 September 2013 Accepted 19 September 2013 Available online 26 September 2013 Keywords: Protein and kinase ...Our results demonstrate that impairments in Nr4a2 expression accompany cognitive deficits in aged mice and rats. Further, HDAC3 contributes to this age-related …While the anterior cingulate (ACC) and retrosplenial (RSC) cortices have been extensively studied for their role in spatial navigation, less is known about how they contribute to associative learning and later memory recall.Janine L Kwapis; The circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian cycle ...Janine L. Kwapis, Timothy J. Jarome, Nicole C. Ferrara, Fred J. Helmstetter. Biology; Research output: Contribution to journal › Article › peer-review. 16 Scopus citations. Overview; Fingerprint; Abstract. Established memories undergo a period of vulnerability following retrieval, a process termed 'reconsolidation.' Recent work has shown ...Timothy J. Jarome, Craig T. Werner, # Janine L. Kwapis, # and Fred J. Helmstetter * Efthimios M. C. Skoulakis, Editor. Author information Article ... Mouledous L, Frances B, et al. Protein degradation, as with protein synthesis, is required not only during long-term spatial memory consolidation but also reconsolidation. Eur J Neurosci. ...White AO, Kramár EA, López AJ, Kwapis JL, Doan J, Saldana D, Davatolhagh MF , Alaghband Y , Blurton-Jones M, Matheos DP , Wood MA (2016) BDNF rescues BAF53b-dependent syn-Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA; Corresponding author: fjh{at}uwm.edu; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. ...Janine L. Kwapis , Contributed equally to this work with: Craig T. Werner, Janine L. Kwapis Affiliation Department of Psychology, University of Wisconsin, Milwaukee, Wisconsin, United States of America ⨯ . Fred J. Helmstetter * E-mail: [email protected] circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian cycle, including memory processes, yet little is understood about how the clock interfaces with memory at a molecular level. The molecular circadian clock consists of four ... While the anterior cingulate (ACC) and retrosplenial (RSC) cortices have been extensively studied for their role in spatial navigation, less is known about how they contribute to associative learning and later memory recall.The First Annual Meeting of the Society for Neuroscience, 1971: Reflections Approaching the 50th Anniversary of the Society's FormationFeb 21, 2023 · Janine Kwapis, assistant professor of biology at Penn State, has been appointed as the first Paul Berg Early Career Professor in the Biological Sciences in recognition of her research contributions, teaching, and service to the Department of Biology and the Eberly College of Science. The professorship was created through an endowment ... Using RNA-sequencing we identified the circadian clock gene Period1 (Per1) as a key mechanism capable of supporting this diurnal fluctuation in memory consolidation, as learning-induced Per1 oscillates in tandem with memory performance in the hippocampus. We then show that local knockdown of Per1 within the DH impairs spatial memory without ...This work was supported by National Institutes of Health Grants MH101491, AG051807, and AG050787 to M.A.W., the National Institute on Aging Grants F32 AG052303 and K99 AG056596 to J.L.K., and in part by the Intramural Research Program of the National Institute on Aging. We thank Dr. Timothy Bredy for his help developing the HA-Nr4a1 virus.Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA ... (NIMH) grants R01MH069558 to F.J.H. and NIMH grant F31MH090685 to J.L.K. We thank Marieke R. Gilmartin and Jonathan L. Lee for technical assistance. Previous Section Next Section ...Chad W Smies, Kasuni K Bodinayake, Janine L Kwapis. Published in. Neurobiology of learning and memory. Pages 107651. Jun 10, 2022. Epub Jun 10, 2022. Abstract The circadian system plays an important role in aligning biological processes with the external time of day.Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Fred J. Helmstetter. Biology; Research output: Contribution to journal › Article › peer-review. 66 Scopus citations. ... of two cues separated by an empty period of time. We have previously shown that trace fear extinction requires the RSC (Kwapis, Jarome, Lee, Gilmartin, & Helmstetter ...This work was supported by NIMH and NIDA grants (MH81004, MH101491, DA025922, DA036984, DA031989) to M.A. Wood and NIA T32 grant AG000096-31 to J.L.K. Go to: GlossaryInternational Journal of Molecular Sciences Editorial Special Issue “Molecular Mechanisms of Memory Formation and Modification” Timothy J. Jarome 1,2,* and Janine L. Kwapis 3,4,* Citation: Jarome, T.J.; Kwapis, J.L. Special Issue “Molecular MechanismsSydney Trask 1 , Nicole C Ferrara 2 , Aaron M Jasnow 3 , Janine L Kwapis 4 Affiliations 1 Department of Psychological Sciences, Purdue University, West Lafayette, IN, 47907, United States. Janine L. Kwapis, Ph.D. Assistant Professor Paul Berg Early Career Professor in the Biological Sciences Department of Biology, Pennsylvania State University Office: 516 Mueller Lab ½ Lab: 508 Mueller Lab University Park, PA 16802 Phone: 814-863-0859 Email: [email protected] Website: www.kwapislab.com CURRENT POSITION Pennsylvania State UniversityJanine L. Kwapis, 1, 2, 3 Yasaman Alaghband, 1, 2 Enikö A. Kramár, 1, 2 Alberto J. López, 1, 2 Annie Vogel Ciernia, 4 André O. White, 5 Guanhua Shu, 1, 2 Diane Rhee, 1, 2 Christina M. Michael, 1, 2 Emilie Montellier, 6 Yu Liu, 7, 8 Christophe N. Magnan, 7, 8 Siwei Chen ... Kwapis JL, et al. Context and auditory fear are differentially ...AU - Kwapis, Janine L. N1 - Funding Information: This work was supported by the National Institutes of Health (grants R00AG056596 and R21AG068444) awarded to J.L.K.; the Whitehall Foundation (grant 2020-05-06 to J.L.K.); and was conducted while Janine Kwapis was a Glenn Foundation for Medical Research and AFAR Grant for Junior Faculty …AU - Kwapis, Janine L. N1 - Funding Information: Funding: This research was funded by NIH grants K99/R00AG056586 (J.L.K.) and R21AG068444 (J.L.K.), Whitehall Foundation Grant #2020-05-06 (J.L.K.), startup funds from the Eberly College of Science and Department of Biology at Pennsylvania State University (J.L.K.) and the National Institute on ...Janine L Kwapis. Affiliations. 1 Department of Psychological Sciences, Purdue University, West Lafayette, IN, 47907, United States. 2 Department of ...Brief Communication NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioningEpigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. by Janine L Kwapis, Yasaman Alaghband, Enikö A Kramár, Alberto J López, Annie Vogel Ciernia, André O White, Guanhua Shu, Diane Rhee, Christina M Michael, Emilie Montellier, Yu Liu, Christophe N Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P Matheos, Marcelo A Wood.The next day, all animals were tested for their responses to the contextual and auditory cues. We found a main effect for drug on the context test (F (2,24) = 6.626, P = 0.005) (Fig. 2A).Fisher LSD post hoc tests revealed significant impairments in retention for the training context in animals that received either 100 μM (P = 0.026) or 200 μM (P = 0.002) concentrations of IU1 relative to ...Christopher W Butler · Ashley A Keiser · Janine L Kwapis · Nicole C Berchtold · Vanessa L Wall · Marcelo A Wood · Carl W Cotman: Inhibitory learning of phototaxis by honeybees in a passive-avoidance task. Paul Marchal · Maria Eugenia Villar · Haiyang Geng · Patrick Arrufat · Maud Combe · Haydée Viola · Isabelle Massou · Martin Giurfa:Christopher W. Butler, 1 Ashley A. Keiser, 1 Janine L. Kwapis, 2 Nicole C. Berchtold, 1 Vanessa L. Wall, 1 Marcelo A. Wood, 1 and Carl W. Cotman 1 Christopher W. Butler 1 Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92617, USAJanine l. kwapis, craftsman house porch columns, kaitlynwillixms
Timothy J. Jarome, Craig T. Werner, Janine L. Kwapis, Fred J. Helmstetter. Research output: Contribution to journal › Article › peer-review. 141 Scopus citations. Overview; Fingerprint; Fingerprint Dive into the research topics of 'Activity dependent protein degradation is critical for the formation and stability of fear memory in the .... Janine l. kwapis
zillow monroe city moBDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens André O. White, Enikö A. Kramár, Alberto J. López, Janine L. Kwapis, John Doan, David Saldana, M. Felicia Davatolhagh, Yasaman Alaghband, Mathew Blurton-Jones, Dina P. Matheos and Marcelo A. Wood () ...Brief Communication The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation Timothy J. Jarome,1 Janine L. Kwapis,1 Jada J. Hallengren,2 Scott M. Wilson,2 and Fred J. Helmstetter1,3 1Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA; 2Department of Neurobiology, University of Alabama, Birmingham, Alabama 35294, USACurriculum Vitae Janine Kwapis 3 7. López AJ, Hemstedt TJ, Jia Y, Hwang PH, Campbell RR, Kwapis JL, White AO, Chitnis O, Scarfone VM, Matheos DP, Lynch G, Wood MA. (2019). Epigenetic regulation of immediate-early gene Nr4a2/Nurr1 in the medial 8.Janine L Kwapis 1 2 3 , Yasaman Alaghband 1 2 , Enikö A Kramár 1 2 , Alberto J López 1 2 , Annie Vogel Ciernia 4 , André O White 5 , Guanhua Shu 1 2 , Diane Rhee 1 2 , Christina M Michael 1 2 , Emilie Montellier 6 , Yu Liu 7 8 , Christophe N Magnan 7 8 , Siwei Chen 7 8 , Paolo Sassone-Corsi 6 , Pierre Baldi 7 8 , Dina P Matheos 1 2 ...Janine L. Kwapis; Yasaman Alaghband; Marcelo A. Wood; Article 15 Jun 2019. Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model.We have previously shown that trace fear extinction requires the RSC (Kwapis, Jarome, Lee, Gilmartin, & Helmstetter, 2014) and have hypothesized that trace …Injection of corticosterone (CORT) in the dorsal hippocampus (DH) can mimic post-traumatic stress disorder (PTSD)—related memory in mice: both maladaptive hypermnesia for a salient but irrelevant simple cue and amnesia for the traumatic context. However, accumulated evidence indicates a functional dissociation within the hippocampus such that contextual learning is primarily associated with ...Janine L Kwapis, Tim J Jarome, Nicole C Ferrara, & Fred J Helmstetter. Context memory formation requires activity-dependent protein degradation in the hippocampus. Patrick K Cullen, Nicole C Ferrara, Shane E Pullins, & Fred J Helmstetter.The molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sensory neurons, a regeneration-incompetent central spinal cord …BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens André O. White, Enikö A. Kramár, Alberto J. López, Janine L. Kwapis, John Doan, David Saldana, M. Felicia Davatolhagh, Yasaman Alaghband, Mathew Blurton-Jones, Dina P. Matheos and Marcelo A. Wood () ...While the anterior cingulate (ACC) and retrosplenial (RSC) cortices have been extensively studied for their role in spatial navigation, less is known about how they contribute to associative learning and later memory recall.Lauren Bellfy 1 2 , Chad W Smies 1 , Alicia R Bernhardt 1 , Kasuni K Bodinayake 1 , Aswathy Sebastian 2 , Emily M Stuart 1 , Destiny S Wright 1 , Chen-Yu Lo 1 , Shoko Murakami 1 , Hannah M Boyd 1 2 , Megan J von Abo 1 , Istvan Albert 2 3 , Janine L Kwapis 4 5Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by the inflammatory response after injury. Here we show that ROS, which promote axonal dieback and degeneration after injury, are also required for axonal regeneration and functional recovery after spinal injury. We f …The circadian system influences many different biological processes, including memory performance. While the suprachiasmatic nucleus (SCN) functions as the brain’s central pacemaker, satellite clocks have also been identified in other brain regions, such as the memory-relevant dorsal hippocampus. Although it is unclear how these …Yasaman Alaghband 1 2 3 , Enikö Kramár 1 3 , Janine L Kwapis 1 4 3 , Earnest S Kim 5 , Thekla J Hemstedt 1 3 , Alberto J López 1 2 3 , André O White 1 2 3 , Amni Al-Kachak 1 3 , Osasumwen V Aimiuwu 1 3 , Kasuni K Bodinayake 1 3 , Nicole C Oparaugo 1 3 , Joseph Han 1 3 , K Matthew Lattal 5 , Marcelo A Wood 6 2 4 3Abstract In the laboratory, memory is typically studied as a de novo experience, in which a naïve animal is exposed to a discrete learning event that is markedly different from its past experiences...Janine L. Kwapis, Department of Psychology, University of Wisconsin, 2441 East Hartford Ave, Milwaukee, WI 53201, USA. ... Kwapis JL, Jarome TJ, Lonergan ME, Helmstetter FJ. Inhibition of protein kinase Mζ erases an established fear memory in the amygdale but not the hippocampus.Fluctuating NMDA Receptor Subunit Levels in Perirhinal Cortex Relate to Their Dynamic Roles in Object Memory Destabilization and ReconsolidationJanine L. Kwapis, 1 Yasaman Alaghband, 1 Alberto J. López, 1 Jeffrey M. Long, 2 Xiang Li, 1 Guanhua Shu, 1 Kasuni K. Bodinayake, 1 Dina P. Matheos, 1 Peter R. Rapp, 2 and ... AG051807, and AG050787 to M.A.W., the National Institute on Aging Grants F32 AG052303 and K99 AG056596 to J.L.K., and in part by the Intramural Research Program of the ...The retrosplenial cortex is important for both the acquisition and retrieval of context fear, as blocking NMDA receptors within the RSC disrupts the retrieval of both recent and remote context fear memory (Corcoran et al., 2011) and blocking protein synthesis in the RSC or silencing the RSC during training impairs the acquisition of contextual ...Epigenetic mechanisms, which control gene expression to produce long-lasting changes in cellular function, may support the formation of fear memory underlying PTSD. We address here the role of epigenetic mechanisms in the formation, storage, updating, and extinction of fear memories. We also discuss methods of targeting these epigenetic ... Janine L. Kwapis , Contributed equally to this work with: Craig T. Werner, Janine L. Kwapis Affiliation Department of Psychology, University of Wisconsin, Milwaukee, Wisconsin, United States of America ⨯ . Fred J. Helmstetter * E-mail: [email protected] animals were handled for several days prior to surgery. Rats that underwent surgery were implanted with bilateral cannulas aimed at the amygdala [anteroposterior [AP], −2.8; Lateral [L], +/− 5.0; Ventral [V], −7.2]. Coordinates were chosen based on a rat brain atlas . Before surgery, each rat was anesthetized with an intraperitoneal ...AU - Kwapis, Janine L. N1 - Funding Information: This work was supported by the National Institutes of Health (grants R00AG056596 and R21AG068444) awarded to J.L.K.; the Whitehall Foundation (grant 2020-05-06 to J.L.K.); and was conducted while Janine Kwapis was a Glenn Foundation for Medical Research and AFAR Grant for Junior Faculty awardee ...Alaghband Y, Kwapis JL, López AJ, White AO, Aimiuwu OV, Al-Kachak A, Bodinayake KK, Oparaugo NC, Dang R, Astarabadi M, Matheos DP, Wood MA (2017) Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory.Janine L. Kwapis, Ph.D. Assistant Professor Paul Berg Early Career Professor in the Biological Sciences Department of Biology, Pennsylvania State University Office: 516 Mueller Lab 1⁄2 Lab: 508 Mueller Lab University Park, PA 16802 Phone: 814-863-0859 Email: [email protected] Website: www.kwapislab.com CURRENT POSITIONFear of movement-related pain leads to two types of avoidance behavior: excessive avoidance and pain-inhibited movement. Excessive avoidance is an absence of movement by fear, and pain-inhibited movements involve a change in motor behavior for the purpose of protecting the painful part. Here, we sought to clarify the acquisition process …2020 Jan;45(2):337-346. doi: 10.1038/s41386-019-0438-0. Epub 2019 Jun 15. Authors. Janine L Kwapis , Yasaman Alaghband , Ashley A Keiser , Tri N Dong ...International Journal of Molecular Sciences Editorial Special Issue "Molecular Mechanisms of Memory Formation and Modification" Timothy J. Jarome 1,2,* and Janine L. Kwapis 3,4,* Citation: Jarome, T.J.; Kwapis, J.L. Special Issue "Molecular MechanismsJanine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA; Corresponding author: fjh{at}uwm.edu; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. ...Janine Kwapis Page 2 • First Place Award for Oral Presentation, UCI ReMIND Emerging Scientists Symposium, UC Irvine 2015 • NIH T32 Institutional Training Grant Recipient, UCI MIND 2014-2016 • NIH F31 Predoctoral Ruth L. Kirschstein National Research Service Award (NRSA) – 3 year fellowship 2011-2013 Janine L. Kwapis (grad student) Chad Smies: Biology: 2020: Janine L. Kwapis (grad student) Is someone missing from the tree? Register/sign in to make changes. Question? Ideas? Want to start a new tree? Contact admin at neurotree dot org - Report bug/errorThis research was supported by the National Institutes of Mental Health (NIMH) Grant R01MH069558 to Fred J. Helmstetter and NIMH Grant F31MH090685 to Janine L. Kwapis. References (24) F.J. Helmstetter et al.Bellfy L, Kwapis JL. Molecular Mechanisms of Reconsolidation-Dependent Memory Updating. International Journal of Molecular Sciences. 21. PMID 32916796 DOI: 10.3390/ijms21186580 0.887 2020 Wright DS, Bodinayake KK, …The broad goal of the proposed project is to understand how long-term memories are stored in the brain through the activity of protein kinase Mzeta (PKM?). Using rats, this project will determine the...Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard Dang, Dina P. Matheos, ...Janine Kwapis Page 2 • First Place Award for Oral Presentation, UCI ReMIND Emerging Scientists Symposium, UC Irvine 2015 • NIH T32 Institutional Training Grant Recipient, UCI MIND 2014-2016 • NIH F31 Predoctoral Ruth L. Kirschstein National Research Service Award (NRSA) – 3 year fellowship 2011-2013Europe PMC is an archive of life sciences journal literature.Janine Kwapis. Janine Kwapis. Janine Kwapis. Madison Clement. Madison Clement ... Robert L. Isaacson. Laszlo Lenard. Robert L. Isaacson. Michael L. Woodruff.Introduction. For decades, researchers have generally agreed that gene expression is a key requirement for long-term memory formation (Alberini, 2009), but only recently were histone modification mechanisms implicated in this process (Barrett and Wood, 2008; Jarome et al, 2014; Kwapis and Wood, 2014; Maddox et al, 2013a).Epigenetics, broadly defined, includes mechanisms that change gene ...Kwapis, Janine Lynn: F31 Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). The Role of Protein Kinase Mzeta in Hippocampal-Dependent Memory Maintenance.Alberto J López 1 , Thekla J Hemstedt 2 , Yousheng Jia 3 , Philip H Hwang 1 , Rianne R Campbell 1 , Janine L Kwapis 2 , Andre O White 4 , Om Chitnis 1 , Vanessa M Scarfone 5 , Dina P Matheos 1 , Gary Lynch 6 , Marcelo A Wood 7Timothy J. Jarome, 1 Janine L. Kwapis, 1 Jada J. Hallengren, 2 Scott M. Wilson, 2 and Fred J. Helmstetter 1, 3 Author information Article notes ... De Jaeger X, Mouledous L, Frances B, Roullet P 2008. Protein degradation, as with protein synthesis, is required during not only long-term spatial memory consolidation but also reconsolidation.PDF | Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both... | Find, read and cite all the research ...The atypical isoform of PKCζ is PKMζ, which has been implicated in the maintenance of long-term fear memories (e.g., Kwapis et al. 2009). Of interest would be whether the FHH strain with a BN5 substitution (FHH-5 BN ) would show recovery of LTM deficits for both the auditory and context cues similar to the FHH-1 BN consomic. Fear of movement-related pain leads to two types of avoidance behavior: excessive avoidance and pain-inhibited movement. Excessive avoidance is an absence of movement by fear, and pain-inhibited movements involve a change in motor behavior for the purpose of protecting the painful part. Here, we sought to clarify the acquisition process …Alberto J López 1 , Enikö Kramár 1 , Dina P Matheos 1 , André O White 1 , Janine Kwapis 1 , Annie Vogel-Ciernia 2 , Keith Sakata 1 , Monica Espinoza 1 , Marcelo A Wood 3 Affiliations 1 Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697 ...Kwapis, Janine Lynn: F31 Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). The Role of Protein Kinase Mzeta in Hippocampal-Dependent Memory Maintenance.Alzheimer's Disease affects 5.4 million Americans [1] and by 2030, approximately 13.8 million people 65 or older are projected to have the disease [2]. Even more individuals will experience normal age...Janine L. Kwapis [email protected] Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, Pennsylvania. Corresponding author: [email protected] Search for more papers by this authorAuthor links open overlay panel Alberto J. López a b c, Thekla J. Hemstedt a c, Yousheng Jia d, Philip H. Hwang a b c, Rianne R. Campbell a b c, Janine L. Kwapis a c, Andre O. White e, Om Chitnis a b c, Vanessa M. Scarfone f, Dina P. Matheos a b c, Gary bKwapis, Janine L López, Alberto J et al. Publication Date 2017-11-01 DOI 10.1016/j.nlm.2017.09.001 Peer reviewed eScholarship.org Powered by the California Digital Library University of California. Distinct roles for the deacetylase domain of HDAC3 in theSep 22, 2011 · All animals were handled for several days prior to surgery. Rats that underwent surgery were implanted with bilateral cannulas aimed at the amygdala [anteroposterior [AP], −2.8; Lateral [L], +/− 5.0; Ventral [V], −7.2]. Coordinates were chosen based on a rat brain atlas . Before surgery, each rat was anesthetized with an intraperitoneal ... Aging impairs both circadian rhythms and memory, though the relationship between these impairments is not fully understood. Circadian rhythms are largely dictated by clock genes within the body's central pacemaker, the suprachiasmatic nucleus (SCN), though these genes are also expressed in local clo …All animals were handled for several days prior to surgery. Rats that underwent surgery were implanted with bilateral cannulas aimed at the amygdala [anteroposterior [AP], −2.8; Lateral [L], +/− 5.0; Ventral [V], −7.2]. Coordinates were chosen based on a rat brain atlas . Before surgery, each rat was anesthetized with an intraperitoneal ...Janine L. Kwapis [email protected] Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, Pennsylvania. Corresponding author: [email protected] Search for more papers by this authorJanine L. Kwapis Scilit Preprints.org Google Scholar Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, PA 16802, USAResearch Summary Molecular and epigenetic mechanisms underlying learning and memory and age-related memory impairments. Huck Graduate Students Lauren Bellfy Chad …To whom all correspondence should be addressed: Janine L. Kwapis, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA; e-mail: [email protected]: 10.3390/ijms22084113 Corpus ID: 233424401; Special Issue "Molecular Mechanisms of Memory Formation and Modification" @article{Jarome2021SpecialI, title={Special Issue "Molecular Mechanisms of Memory Formation and Modification"}, author={Timothy J Jarome and Janine L. Kwapis}, journal={International Journal of Molecular Sciences}, year={2021}, volume={22} }1. To whom all correspondence should be addressed: Janine L. Kwapis, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA; e-mail: [email protected]. Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory ConsolidationJanine L. Kwapis, Timothy J. Jarome, Nicole C. Ferrara, Fred J. Helmstetter. Biology; Research output: Contribution to journal › Article › peer-review. 16 Scopus citations. Overview; Fingerprint; Abstract. Established memories undergo a period of vulnerability following retrieval, a process termed 'reconsolidation.' Recent work has shown ...Janine L. Kwapis (301 Qureshey Research Lab, University of California Center for the Neurobiology of Learning and Memory Irvine Center for Addiction Neuroscience (ICAN), University of California Institute for Memory Impairments and Neurological Disorders ...Protein Kinase Mzeta. PKMζ is an atypical isoform of protein kinase C (PKC) that is believed to actively maintain those cellular changes that occur during memory formation in order to preserve the memory engram over time. In vitro work has demonstrated that PKMζ is both necessary and sufficient to maintain established long-term potentiation ...7 Des 2016 ... Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala. Janine L Kwapis, ...Janine L Kwapis; Yasaman Alaghband; Marcelo A Wood; Original Article 07 Dec 2016. Sex Differences in ... Rachel L Navarra; Brian D Clark; Barry D Waterhouse; Original Article 02 Dec 2016.Kwapis JL, Alaghband Y, López AJ, White AO, Campbell RR, Dang RT, Rhee D, Tran AV, Carl AE, Matheos DP, et al. 2017. Context and auditory fear are differentially regulated by HDAC3 activity in the lateral and basal subnuclei of the amygdala. Neuropsychopharmacology 42: 1284-1294. [PMC free article] [Google Scholar] Kwapis JL, Wood MA. 2014.Jul 8, 2015 · Jarome TJ, Kwapis JL, Werner CT, Parsons RG, Gafford GM, Helmstetter FJ (2012). The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation. Learn Mem 19: 300–306. [PMC free article] [Google Scholar] Jarome TJ, Werner CT, Kwapis JL, Helmstetter FJ (2011). Histone acetylation is a fundamental epigenetic mechanism that is dynamically regulated during memory formation. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) compete to modulate histone acetylation, allowing for rapid changes in acetylation in response to a learning event.Alaghband, Yasaman ; Kramár, Enikö ; Kwapis, Janine L. et al. / CREST in the nucleus accumbens core regulates cocaine conditioned place preference, cocaine-seeking behavior, and synaptic plasticity.Alberto J López 1 , Enikö Kramár 1 , Dina P Matheos 1 , André O White 1 , Janine Kwapis 1 , Annie Vogel-Ciernia 2 , Keith Sakata 1 , Monica Espinoza 1 , Marcelo A Wood 3 Affiliations 1 Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697 ...Previous work from our lab (Kwapis et al., 2011, Kwapis et al., 2014, Kwapis et al., 2015) has demonstrated that a 6-trial trace fear conditioning protocol with a variable intertrial interval (ITI) of 240 ± 20 s produces approximately the same level of freezing as 4 trials of delay fear conditioning with a shorter ITI of 110 ± 20 s.Janine Kwapis Pennsylvania State University | Penn State · Department of Biology PhD Connect with experts in your field Join ResearchGate to contact this researcher and connect with your...Author links open overlay panel Sydney Trask a, Nicole C. Ferrara b, Aaron M. Jasnow c, Janine L. Kwapis d. Show more. Add to Mendeley. Share. ... J.L. Kwapis et al. The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning. Neurobiol. Learn. Mem. (2015)Timothy J. Jarome, 1 Janine L. Kwapis, 1 Jada J. Hallengren, 2 Scott M. Wilson, 2 and Fred J. Helmstetter 1, 3 Author information Article notes ... McGauran AM, De Jaeger X, Mouledous L, Frances B, Roullet P 2008. Protein degradation, as with protein synthesis, is required during not only long-term spatial memory consolidation but also ... Kwapis JL, …Feb 1, 2023 · Janine L. Kwapis, Y. Alaghband, +14 authors M. Wood. Biology, Psychology. Nature Communications. 2018; TLDR. It is shown that epigenetic regulation of clock gene ... Injection of corticosterone (CORT) in the dorsal hippocampus (DH) can mimic post-traumatic stress disorder (PTSD)—related memory in mice: both maladaptive hypermnesia for a salient but irrelevant simple cue and amnesia for the traumatic context. However, accumulated evidence indicates a functional dissociation within the hippocampus such that contextual learning is primarily associated with ...Jarome, Timothy J., Craig T. Werner, Janine L. Kwapis, and Fred J. Helmstetter. "Activity Dependant Protein Is Critical for the Formation and Stability of Fear Memory in the Amygdala." PlOS One 6.9 (2011): n. pag. Web.Janine L. Kwapis, Timothy J. Jarome, Fred J. Helmstetter. Biology; Research output: Contribution to journal › Article › peer-review. 14 Scopus citations. Overview; Fingerprint; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. Whether this ...The next day, all animals were tested for their responses to the contextual and auditory cues. We found a main effect for drug on the context test (F (2,24) = 6.626, P = 0.005) (Fig. 2A).Fisher LSD post hoc tests revealed significant impairments in retention for the training context in animals that received either 100 μM (P = 0.026) or 200 μM (P = 0.002) concentrations of IU1 relative to ...Yasaman Alaghband, Enikö Kramár, Janine L. Kwapis, Earnest S. Kim, Thekla J. Hemstedt, ... (DA025922) to K.M.L. and M.A.W., the National Institute of Mental Health Grant (MH101491) to M.A.W., and National Institute on Drug Abuse and National Institute on Aging Grants (F32 DA043998 and T32 AG000096-33) to Y.A. ...Welcome to the Kwapis Lab! We are located at the University Park campus of Pennsylvania State University in the department of Biology . Our lab is part of the Eberly College of Science , and we’re affiliated with the Huck Institutes of the Life Sciences .. 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